Martin Hulce

Martin Hulce, Ph.D.

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Martin Hulce, Ph.D.
Professor
Organic Chemistry

402.280.2271
Rigge Science Building 226 mhulce@creighton.edu

Martin Hulce

Dr. Hulce leads the Department of Chemistry's Laboratory for Metalloorganic Chemistry.

Dr. Hulce's laboratory investigates new synthetic methods in organic chemistry and the preparation of small, functionally rich organic molecules.  Ongoing work includes the development of new allene-forming reactions, the synthesis of modified amino acids for solid phase peptide synthesis, the generation, use and detection of singlet oxygen, and halogen-specific aromatic dehalogenation reactions.

Education

Ph.D. (1983) Johns Hopkins University
M.A. (1980) Johns Hopkins University
B.S. (1978) Butler University

Selected Publications

Munt, D. J.; Grana, A.; Hulce, M.; Fusaro, R. M.; Dash, A. K.  “Effect of Simultaneous Administration of Dihydroxyacetone on the Diffusion of Lawsone Through Various In Vitro Skin Models.”  AAPS PharmSciTech 2015, 16;  DOI: 10.1208/s12249-015-0335-8.

Smith, D. D.; Gallagher, A. T.; Crowley, V.; Gergens, W. M.; Abel, P.W.; Hulce, M.  “An Efficient  Synthesis of of 4(5)-Benzyl-L-Histidines Employing Catalytic Transfer Hydrogenation at Elevated Temperatures.” Synthesis 2014, 46, 515-521.  DOI: 10.1055 /s-033-1340462.

Carney, J. M.; Hammer, R. J.; Hulce, M.; Lomas, C. M.; Miyashiro, D.  “Microphotochemistry Using 5 mm Light-emitting Diodes: Energy-efficient Photooxidations.”  Synthesis 2012, 44, 2560-2566.  DOI: 10.1055/s-0031-1289764.

Carney, J. M.; Hammer, R. J.; Hulce, M.; Lomas, C. M.; Miyashiro, D.  “High-Efficiency Microphotooxidation Using Milliwatt Light-emitting Diode Sources,” Tetrahedron Letters 2011, 52, 352-355.   DOI:10.1016/j.tetlet.2010.11.071.

Smith, D. D.; Gallagher, A.; Gergens, W.; Crowley, V.; Abel, P.W.; Hulce, M.  “Revisiting and Optimizing the Synthesis of 4-Benzyl-L-Histidine and Analogues.”  in Peptides: Building Bridges, Lebl, M., ed; Prompt Scientific Publishing: San Diego, 2011, 34-35.

Smith, D.D.; Mao, M.; Young, H.; Hulce, M. “Synthesis of 4-Arylmethyl-L-hisitidine analogues for Structure-Activity Studies of Position 10 of CGRP,” Advances in Experimental Medicine & Biology 2009, 611, 131-132.

Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D. “N-Terminal bis(2-Chloroethyl)amino & Fluorosulfonyl Analogues of Calcitonin Gene-Related Peptide(8-37):  Irreversible Antagonists at Calcitonin Gene-Related Peptide Receptors,” Chemical Biology & Drug Design 2007, 70, 216-226.

Taylor, C.K.; Smith, D.D.; Hulce, M.; Abel, P.W.  “Pharmacological Characterization of Novel High Affinity CGRP Receptor Antagonists that are Selective for Human CGRP Receptors,” Journal of Pharmacology & Experimental Therapeutics 2006, 319, 749-757.

Mattson, B.; Hulce, M; Cheng, W.; Greimann, J.; Hoette, T; Menzel, P. “Propanol to Propane.  An Advanced Laboratory Experiment Using Two Gas-phase Heterogeneous Catalysts,” Journal of Chemical Education 2006, 83, 421-424.

Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D. “Solvent Effects on Coupling Yields During Rapid Solid Phase Synthesis of CGRP(8-37) Employing in situ Neutralization,” Journal of Peptide Research 2005, 65, 84-89.

Reidelberger, R.D.; Hernandez, J.; Fritzsch, B.; Hulce, M.  “Abdominal Vagal Mediation of the Satiety Effects of CCK in Rats,” American Journal of Physiology - Regulatory, Integrative & Comparative Physiology 2004, 286, R1005-R1012.

Reidelberger, R.D.; Castellanos, D.; Hulce, M. “Effects of Peripheral CCK Receptor Blockade on Food Intake in Rats,” American Journal of Physiology - Regulatory, Integrative & Comparative Physiology 2003, 285, R429-R437.

Smith, D.D.; Saha, S.; Fang, G.; Schaffert, C.; Waugh, D.J.J.; Zeng, W.; Toth, G.; Hulce, M.; Abel, P.W.  “Modifications to the N-terminus but not the C-terminus of Calcitonin gene-Related Peptide(8-37) Produces Antagonists with Increased Affinity for CGRP Receptors,” Journal of Medicinal Chemistry 2003, 46, 2427-2435.

Reidelberger, R.D.; Heimann, D.; Kelsey, L.; Hulce, M. “Effects of Peripheral CCK Receptor Blockade on Feeding Responses to Duodenal Nutrient Infusions in Rats,” American Journal of Physiology - Regulatory, Integrative & Comparative Physiology  2003, 284, R389-R398.

Reidelberger, R.D.; Kelsey, L.; Heimann, D.; Hulce, M. “Effects of Peripheral CCK Blockade on Gastric Emptying in Rats,” American Journal of Physiology - Regulatory, Integrative & Comparative Physiology  2003, 284, R66